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New MONET Publication in Nano Letters

A team from the Steinmetz and Craig labs built an internal polymer “backbone” using a maleimide cross-linker to covalently interlink viral coat proteins inside the capsid cavity, while the native VLPs are held together by only noncovalent bonding between subunits. Endoskeleton-armored VLPs exhibited significantly improved thermal stability, increased resistance to denaturants, and enhanced mechanical performance.

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