New MONET Publication in Chem Comm

A team from the Klausen, Craig, and Kulik labs report the synthesis of two new examples of 7- and 8-membered sila-cycloalkynes, as well as an investigation of their strain-promoted reactivity with azides. The results demonstrate that measurable angle-strain alone is insufficient for room-temperature cycloaddition, influencing design principles in an area broadly relevant to organic chemists and chemical biologists.

Article Link